Who am I?
Hi, my name is Joshua (Wing Kei) Ho. I am currently a PhD candidate at the
School of Information Technologies,
The University of Sydney and NICTA.
I am jointly supervised by Dr. Michael Charleston, Prof. Cris dos Remedio and Prof. Albert Zomaya.
I can be contacted at . My full CV is available here.
Brief Biography
I moved to Australia for tertiary studies after completing the school certificate in Hong Kong in 2002. After completing the first year of a Bioinformatics/Science degree
at La Trobe University, I transferred to the University of Sydney where I completed a
Bachelor of Science (Advanced) in Biology, Biochemistry and Computer Science. I was awarded first class honours and a University Medal.
Now I am staying on for a PhD at the same university. I am a winner of the Australian Postgraduate Award and the
NICTA Research Project Award.
Research Interest
My current PhD research project focuses on the computational and biological issues related to systems-level biological data analysis. I am always open to new collaboration opportunities in the general areas of systems biology and bioinformatics.
I have experience and interest in the following research areas:
- Microarray data analysis
- Using systems-level data for medical diagnosis
- Antibody microarray analysis
- Alternative splicing of RNA transcripts
- Evolutionary origin of complex gene regulatory network (GRN)
- Inference of GRNs from microarray data
- Analysis and visualization of complex networks
- Graph drawing
- Visualization
- Proteomics
- Data mining in large biological databases
- Machine learning using graphical models
- Software engineering
- Software testing
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Publications
- Ho JWK, Stefani M, dos Remedios CG, Charleston MA (2009) A model selection approach to discover age-dependent gene expression patterns using quantile
regression models. BMC Genomics, accepted
- Xie X, Ho J Murphy C, Kaiser G, Xu B, Chen TY (2009) Application of Metamorphic Testing to Supervised Classifiers. In Proceedings of The 9th International Conference on Quality Software, accepted
- Mohamed A, Koundinya R, Junius F, Dyer W, Yong A, Ho J, Kritharides L, Freedman B, dos Remedios C (2009) CD antibody microarrays as an objective tool to differentiate between inflammatory conditions of coronary arteries. In Proceedings of The Cardiac Society of Australia and New Zealand (CSANZ) 57th Annual Scientific Meeting, accepted
- Estigoy CB, Ponten F, Odeberg J, Herbert B, Guilhaus M, Charleston M, Ho JWK, Cameron D, dos Remedios CG (2009)
Intercalated Discs: Multiple proteins perform multiple functions in non-failing and failing human hearts. Biophy. Rev., 1, 43-49
- Jermiin LS, Ho JWK, Lau KW, Jayaswal V (2009) SeqVis: A tool for detecting compositional heterogeneity
among aligned nucleotide sequences. In Bioinformatics for DNA sequence analysis (Ed. Posada D), Humana Press, Totowa, NJ. 65-91
- Chen TY, Ho JWK, Liu H, Xie X (2009)
An innovative approach for testing bioinformatics programs using metamorphic testing.
BMC Bioinformatics, 10, 24 [labeled as "Highly accessed" by BMC Bioinformatics]
- Hassan MR, Hossain MM, Bailey J, Macintyre G, Ho JWK, Kotagiri R (2009)
A voting approach to identify a
small number of highly predictive genes using multiple classifiers. BMC Bioinformatics, 10, S19
- Ho JWK, Koundinya R, Caetano TS, dos Remedios CG, Charleston MA (2008)
Inferring differential leukocyte activity from antibody microarrays using a latent variable model.
Genome Informatics, 21, 126-137
- Ho JWK, Stefani M, dos Remedios CG, Charleston MA (2008)
Differential variability analysis of gene expression and its application to human diseases, Bioinformatics, 24, i390-i398
- Ho JWK, Charleston MA (2007)
Modeling the Evolution of Gene Regulatory Networks.
In Proceedings of The Eighth International Conference on Systems Biology (ICSB 2007), Long Beach, USA
- Ho JWK, Morrissey B, Downard KM (2007)
A Computer Algorithm for the Identification of Protein Interaction from the Spectra of Masses (PRISM). J. Am. Soc. Mass Spectrom., 18, 563-566
- Ho JWK, Adams CE, Lew JB, Matthews TJ, Ng CC, Shahabi-Sirjani A, Tan LH, Zhao Y,
Easteal S, Wilson SR, Jermiin LS (2006) SeqVis: Visualization of compositional heterogeneity in large alignments of nucleotides. Bioinformatics, 22(17), 2162-2163
- Ho JWK, Manwaring T, Hong SH, Roehm U, Fung DCY, Xu K, Kraska T, Hart D (2006)
PathBank: Web-based Querying and Visualization of an Integrated Biological Pathway Database.
In Banissi E, Sarfraz M, Huang ML, Wu Q (Eds) Computer Graphics, Imaging and Visualization
- Techniques and Application (Proceedings of CGIV2006), IEEE Computer Society,84-89
- Ho J, Lukov L, Chawla S (2005)
Sequential Pattern Mining with Constraints on Large Protein Databases.
In Chakrabarti S, Sudarshan S, Radha Krishnan P (Eds) Proceedings of the 12th
International Conference on Management of Data (COMAD 2005b), 89-100
- Ho J, Hong SH (2005) Drawing Clustered Graph in Three Dimensions. In Haely P, Nikolov NS
(Eds) Proceedings of the 13th International Symposium of Graph Drawing (GD2005). Lecture
Notes in Computer Science, Springer, 492-502
- Ahmed A, Dwyer T, Foster M, Fu X, Ho J, Hong SH, Koschutzki D, Murray C, Nikolov N, Taib
R, Tarassov A, Xu K, (2005) GEOMI:GEOmetry for Maximum Insight. In Haely P, Nikolov NS
(Eds) Proceedings of the 13th International Symposium of Graph Drawing (GD2005). Lecture
Notes in Computer Science, Springer,468-479
Poster
- Ho JWK (2008) Towards a Bayesian network approach for microarray gene set analysis.
The fourth ISCB Student Symposium, Toronto, Canada
- Ho JWK, Stefani M, dos Remedios C and Charleston MA (2007) Computational Genomics of The Failing Heart
ICE-EM Summer Symposium in Bioinformatics (BioinfoSummer 2007), Canberra, Australia [Winner of the Hilary Booth Prize for the best poster]
- Ho JWK, Charleston MA (2007) Modeling the Evolution of Gene Regulatory Networks
The Eighth International Conference on Systems Biology (ICSB 2007), Long Beach, USA
- Ho JWK, Charleston MA(2007) Assessing Limitations of Gene Regulatory Network Inference Methods
The Fifth Asia Pacific Bioinformatics Conference (APBC 2007), Hong Kong, China
- Ho JWK, Charleston MA (2006) Evolving and Simulating Gene Regulatory Networks
The First Bioinformatics Australia Conference, Sydney, Australia
Thesis
- Ho JWK (2006) Computational Analysis of Evolution and Inference of Gene Regulatory Networks. BSc (Advanced) (Honours) Thesis, School of Biological Sciences, The University of Sydney
Software
- Heart Tissue Bank - A SQL database management system for a collection of human heart tissues (restricted access)
- SeqVis - A tool to visualize compositional heterogeneity in large alignmnet of
nucleotide sequences.
- GNLab - A tool of large-scale analysis of gene regulatory network
- PexSPAM - A tool for mining high-confident sequential features for protein secondary structure prediction
- GEOMI - A 3D visual analytic tool. It includes a few modules for clusterd graph drawing that I developed. A gallery of
3D clustered graph visualization is available here .
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